| Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram. | |
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MedLine Citation:
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PMID: 20680188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Omega-3 fatty acid (O3FA) levels and dimensional personality measures have been associated with major depression and the course of depressive illness. We sought to study the utility of O3FA levels and dimensional personality measures as predictors of early improvement with escitalopram. METHODS: Twenty-four participants were enrolled in an open-label trial of escitalopram 10 mg/d for 4 weeks. Baseline erythrocyte O3 levels and dimensional personality assessments were obtained. RESULTS: Using a conservative, intention-to-treat analysis, baseline neuroticism (r = -0.57; P = .007), as measured by the Revised NEO Personality Inventory but not erythrocyte O3 levels, was correlated with improvements on escitalopram. A facet analysis of the neuroticism domain showed the relationship with antidepressant response to be focused on trait anxiety (r = -0.65; P = .002). CONCLUSIONS: Anxiety may have important prognostic implications on subsequent response to selective serotonin reuptake inhibitors, such as escitalopram. |
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Authors:
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Jess G Fiedorowicz; Nancy Hale; Arthur A Spector; William H Coryell |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists Volume: 22 ISSN: 1547-3325 ISO Abbreviation: Ann Clin Psychiatry Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2011-01-04 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8911021 Medline TA: Ann Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
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Departments of Psychiatry and Epidemiology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA. jess-fiedorowicz@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents, Second-Generation / adverse effects, therapeutic use* Anxiety Disorders / blood, drug therapy, psychology Character* Citalopram / adverse effects, therapeutic use* Depressive Disorder, Major / blood, drug therapy*, psychology Erythrocytes / metabolism Fatty Acids, Omega-3 / blood* Female Humans Male Middle Aged Neurotic Disorders / blood, drug therapy*, psychology Personality Inventory / statistics & numerical data* Prognosis Prospective Studies Psychometrics Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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1K23MH083695-01A210/MH/NIMH NIH HHS; 3 UL1 RR024979-03S4/RR/NCRR NIH HHS; L30 MH075180-01/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 0/Fatty Acids, Omega-3; 59729-33-8/Citalopram |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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