| Neurotensin selectively facilitates glutamatergic transmission in globus pallidus. | |
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MedLine Citation:
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PMID: 16814931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tridecapeptide neurotensin has been demonstrated to modulate neurotransmission in a number of brain regions. There is evidence that neurotensin receptors exist in globus pallidus presynaptically and postsynaptically. Whole-cell patch-clamp recordings were used to investigate the modulatory effects of neurotensin on glutamate and GABA transmission in this basal ganglia nucleus in rats. Neurotensin at 1 microM significantly increased the frequency of glutamate receptor-mediated miniature excitatory postsynaptic currents. In contrast, neurotensin had no effect on GABA(A) receptor-mediated miniature inhibitory postsynaptic currents. The presynaptic facilitation of neurotensin on glutamatergic transmission could be mimicked by the C-terminal fragment, neurotensin (8-13), but not by the N-terminal fragment, neurotensin (1-8). The selective neurotensin type-1 receptor antagonist, SR48692 {2-[(1-(7-chloro-4-quinolinyl)-5-2(2,6-dimethoxyphenyl)pyrazol-3-yl)carbonylamino]-tricyclo(3.3.1.1.(3.7))-decan-2-carboxylic acid}, blocked this facilitatory effect of neurotensin, and which itself had no effect on miniature excitatory postsynaptic currents. The specific phospholipase C inhibitor, U73122 {1-[6-[[17beta-3-methoyyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione}, significantly inhibit neurotensin-induced facilitation on glutamate release. Taken together with the reported postsynaptic depolarization of neurotensin in globus pallidus, it is suggested that neurotensin excites the globus pallidus neurons by multiple mechanisms which may provide a rationale for further investigations into its involvement in motor disorders originating from the basal ganglia. |
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Authors:
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L Chen; K K L Yung; W H Yung |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-11 |
Journal Detail:
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Title: Neuroscience Volume: 141 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 1871-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China. chenleiqd@163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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pharmacology Animals Animals, Newborn Bicuculline / pharmacology Dose-Response Relationship, Radiation Drug Interactions Electric Stimulation / methods Enzyme Inhibitors / pharmacology Estrenes / pharmacology Excitatory Postsynaptic Potentials / drug effects, physiology, radiation effects GABA Antagonists / pharmacology Globus Pallidus / cytology* Glutamic Acid / metabolism* Neural Inhibition / drug effects, physiology, radiation effects Neurons / drug effects*, metabolism Neurotensin / antagonists & inhibitors, pharmacology* Patch-Clamp Techniques / methods Pyrazoles / pharmacology Pyrrolidinones / pharmacology Quinolines / pharmacology Rats Rats, Sprague-Dawley Synaptic Transmission / drug effects* Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Enzyme Inhibitors; 0/Estrenes; 0/GABA Antagonists; 0/Pyrazoles; 0/Pyrrolidinones; 0/Quinolines; 112648-68-7/1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 146362-70-1/SR 48692; 39379-15-2/Neurotensin; 4368-28-9/Tetrodotoxin; 485-49-4/Bicuculline; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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