| Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia. | |
| | |
MedLine Citation:
|
PMID: 15090966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: External cooling is commonly used to force induction of mild hypothermia but requires equipment, has a slow onset of action, and must be prolonged to provide permanent neurologic benefits after hypoxic-ischemia. It is unknown whether the method for inducing mild hypothermia affects neurologic outcome after near-drowning. The objective of the study was to induce mild hypothermia with neurotensin analog NT77 or external cooling in a rat model of near-drowning. We hypothesize that NT77 would be more effective for improving neurologic outcome than external cooling of the same duration. DESIGN: Rats were randomized to a normothermic control, neurotensin-induced hypothermia, brief external cooling, or prolonged external cooling group after asphyxial cardiac arrest. SETTING: Laboratory investigation. SUBJECTS: Forty-eight rats. INTERVENTIONS: Mild hypothermia was induced by external cooling for 4 hrs (brief external cooling) or 24 hrs (prolonged external cooling) or by neurotensin-induced hypothermia administration 30 mins after asphyxial cardiac arrest in rats. MEASUREMENTS: Outcome was assessed by a neurologic deficit score, the Morris water maze, and CA1 hippocampus histology 15 days after resuscitation. MAIN RESULTS: Neurologic deficit score at 72 hrs after asphyxial cardiac arrest was lower with neurotensin-induced hypothermia (score, 0) and prolonged external cooling (score, 0) vs. normothermic control (score, 20) and brief external cooling (score, 18; p <.05). Latency time in the Morris water maze 15 days after asphyxial cardiac arrest was decreased with neurotensin-induced hypothermia (14+/-11 secs) and prolonged external cooling (18+/-9 secs) vs. normothermic control (74+/-17 secs) and brief external cooling (78+/-18 secs, p <.05). There was less ischemic neuronal damage with neurotensin-induced hypothermia (28+/-24%) and prolonged external cooling (21+/-14%) vs. normothermic control (61+/-32%) and brief external cooling (51+/-32%). CONCLUSIONS: Neurotensin-induced hypothermia improved neurologic outcome after asphyxial cardiac arrest in rats vs. brief external cooling but was comparable to prolonged external cooling. |
| | |
Authors:
|
Laurence M Katz; Amanda Young; Jonathan E Frank; Yuanfan Wang; Kyunam Park |
Related Documents
:
|
891756 - The effect of thermal injury on plasma carnitine in rats. 2388946 - Adaptation of body temperature and nociception to cold stress in preweanling rats. 1539726 - Prolonged stable hypothermia: effect on blood gases and ph in rats and ground squirrels. 2578366 - Effects of body temperature elevation on auditory nerve-brain-stem evoked responses and... 12778216 - Carcinogenesis bioassay of c.i. acid red 14 (cas no. 3567-69-9) in f344/n rats and b6c3... 11785906 - Effect of phenobarbital and spironolactone treatment on the oxidative metabolism of ant... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Critical care medicine Volume: 32 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 2004 Mar |
Date Detail:
|
Created Date: 2004-04-19 Completed Date: 2004-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 806-10 Citation Subset: AIM; IM |
Affiliation:
|
University of North Carolina School of Medicine, Chapel Hill, NC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Asphyxia / therapy Disease Models, Animal Heart Arrest / therapy Hypothermia, Induced / methods* Hypoxia, Brain / prevention & control* Near Drowning / therapy* Neurotensin / analogs & derivatives*, therapeutic use* Random Allocation Rats Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
39379-15-2/Neurotensin |
| Comments/Corrections | |
Comment In:
|
Crit Care Med. 2004 Mar;32(3):897-9
[PMID:
15090990
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear fac...
Next Document: Accuracy of the double indicator method for measurement of extravascular lung water depends on the t...