Document Detail


Neurotensin: effects of hypothalamic and intravenous injections on eating and drinking in rats.
MedLine Citation:
PMID:  6685868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate a role for the brain-gut peptide neurotensin (NT) in ingestive behavior, changes in food and water intake of food-deprived rats were examined following injection of NT into the paraventricular hypothalamic nucleus (PVN) or the mesenteric vein. Unilateral PVN NT (2.5, 5.0, 10.0 micrograms/0.3 microliter) produced substantial dose-dependent reductions in total food intake 0.5, 1, and 4 hr postinjection. In contrast, PVN NT had no effect on water intake and produced no change in grooming, rearing, sleeping, resting or locomotor activity. Bilateral PVN NT at a high dose (10.0 micrograms/side) suppressed consumption of solid or liquid diet in food-deprived rats, but did not affect water intake in water-deprived rats. This specificity is consistent with a role for CNS NT in feeding behavior. Intravenous NT (1-1000 pmole/kg/min for 30 min) did not specifically suppress food intake; however, low doses did increase water intake in food-deprived rats. These findings do not support a role for plasma NT in feeding, but do suggest that it may play a role in drinking behavior.
Authors:
B G Stanley; B G Hoebel; S F Leibowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  4     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1983 Jul-Aug
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-500     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Drinking Behavior / drug effects*
Feeding Behavior / drug effects*
Food Deprivation
Humans
Injections, Intravenous
Injections, Intraventricular
Male
Motor Activity / drug effects
Neurotensin / administration & dosage,  pharmacology*
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Rats
Rats, Inbred Strains
Sleep / drug effects
Stereotyped Behavior / drug effects
Grant Support
ID/Acronym/Agency:
MH 22879/MH/NIMH NIH HHS; MH 35740/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
39379-15-2/Neurotensin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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