| Neurotensin analog NT69L induces rapid and prolonged hypothermia after hypoxic ischemia. | |
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MedLine Citation:
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PMID: 11733287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether the neurotensin analog NT69L, administered systemically, could induce mild brain hypothermia after asphyxial cardiac arrest (ACA) in rats. METHODS: The study design was experimental, blinded, randomized, and approved by the animal use committee. All rats had continuous monitoring of brain temperature and sustained 8 minutes of ACA, resuscitation, and either saline or NT69L intravenously after return of spontaneous circulation (ROSC). Rats surviving 14 days after ACA had a neurological deficit score (NDS) and a Morris Water Maze (MWM) test. RESULTS: Seven of eight rats in each group survived 14 days. Brain temperature was less than 35 degrees C 13.1 +/- 3 minutes (mean +/- standard deviation) after NT69L vs controls that remained 37.5 degrees C at the same ambient temperature (p < 0.05 ANOVA). The NT69L group remained below 35 degrees C for 300 +/- 100 minutes while the controls remained at 37.5 +/- 0.5 degrees C. The NDS in the NT69L rats was 3 +/- 3% vs controls 26 +/- 8% (p < 0.05, Kruskal-Wallis, 0% = normal, 100% = brain dead). The NT69L rats performed better on the MWM vs the controls (22 +/- 8 sec vs 45 +/- 26 sec, respectively, p < 0.05 ANOVA). CONCLUSIONS: NT69L induced rapid and prolonged mild brain hypothermia after ACA in this rat model and reduced neurological deficits. |
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Authors:
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L M Katz; Y Wang; B McMahon; E Richelson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Volume: 8 ISSN: 1069-6563 ISO Abbreviation: Acad Emerg Med Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-04 Completed Date: 2002-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9418450 Medline TA: Acad Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 1115-21 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. lkatz@med.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Gas Analysis Cardiopulmonary Resuscitation Disease Models, Animal Heart Arrest / complications, therapy Hypothermia / chemically induced*, physiopathology Hypoxia-Ischemia, Brain / etiology, prevention & control* Infusions, Intravenous Male Neurotensin / administration & dosage, analogs & derivatives*, pharmacology* Peptide Fragments / administration & dosage, pharmacology* Probability Random Allocation Rats Rats, Sprague-Dawley Reference Values Sensitivity and Specificity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/neurotensin 69L; 39379-15-2/Neurotensin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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