| Neurosurgical and immunological implications of primary cerebral amyloid (congophilic) angiopathy. | |
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MedLine Citation:
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PMID: 6447839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two cases of histologically documented primary cerebral amyloid complicated by spontaneous intracerebral hematoma are reported. The neurosurgical implications of this disease are reviewed briefly. Immunological studies in one patient, believed to be a rare survivor of an intracerebral hemorrhage from nonfamilial primary cerebral amyloid angiopathy, demonstrated an increased percentage of B cells within both the cerebrospinal fluid (CSF) and the blood compartments. Hypofunction of CSF concanavalin A-activated suppressor cells with respect to B and T cell targets was shown. The blood suppressor cells from the patient were similar to those of an age-matched control. Compartmental central nervous system suppressor cell dysfunction resulting in B cell activation could play a role in facilitating amyloid deposits in the brain. The mechanisms responsible for the compartmental and limited suppressor cell dysfunction are unknown. |
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Authors:
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S S Rengachary; L S Racela; I Watanabe; N Abdou |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurosurgery Volume: 7 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-11-25 Completed Date: 1980-11-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid
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analysis Amyloidosis / complications, immunology, pathology, surgery* B-Lymphocytes / immunology Cerebral Hemorrhage / etiology Humans Male Middle Aged T-Lymphocytes / immunology T-Lymphocytes, Regulatory / immunology |
| Grant Support | |
ID/Acronym/Agency:
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1321//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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