| Neurosteroids in the brain of handling-habituated and naive rats: effect of CO2 inhalation. | |
| | |
MedLine Citation:
|
PMID: 7813554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In rats habituated to the manipulation that precedes killing (handling-habituated) the cerebral cortical concentrations of pregnenolone and progesterone were significantly lower (-57% and -69%, respectively) than in naive animals. An acute stress, induced by CO2 inhalation, elicited a marked increase in the concentrations of pregnenolone, progesterone and deoxycorticosterone in the brain cortex and hippocampus of handling-habituated rats. An accepted stress, such as foot shock, also enhanced the brain cortical levels of pregnenolone, progesterone and deoxycorticosterone in handling-habituated rats. These data show that the rat brain cortical and hippocampal steroid content is related to the 'emotional state' of the animal. |
| | |
Authors:
|
M L Barbaccia; G Roscetti; M Trabucchi; T Cuccheddu; A Concas; G Biggio |
Related Documents
:
|
18723164 - Early life stress alters behavior, immunity, and microbiota in rats: implications for i... 21569544 - Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models ... 10373244 - Neurochemical characteristics and behavioral responses to psychological stress in ovari... 21933864 - Glucocorticoids disrupt neuroendocrine and behavioral responses during lactation. 12642314 - Suppressive effects of selectin inhibitor skk-60060 on the leucocyte infiltration durin... 7169984 - Alkalinization of the incubation medium by rat and rabbit renal cortical slices. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 261 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 317-20 Citation Subset: IM |
Affiliation:
|
Dipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Animals Brain Chemistry / physiology* Carbon Dioxide / administration & dosage, pharmacology* Cerebral Cortex / drug effects, metabolism Desoxycorticosterone / metabolism Electroshock Handling (Psychology)* Hippocampus / drug effects, metabolism Male Pregnenolone / metabolism Progesterone / metabolism Rats Rats, Sprague-Dawley Steroids / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Steroids; 124-38-9/Carbon Dioxide; 145-13-1/Pregnenolone; 57-83-0/Progesterone; 64-85-7/Desoxycorticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the por...
Next Document: Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-...