Document Detail

Neurosteroids in the brain of handling-habituated and naive rats: effect of CO2 inhalation.
MedLine Citation:
PMID:  7813554     Owner:  NLM     Status:  MEDLINE    
In rats habituated to the manipulation that precedes killing (handling-habituated) the cerebral cortical concentrations of pregnenolone and progesterone were significantly lower (-57% and -69%, respectively) than in naive animals. An acute stress, induced by CO2 inhalation, elicited a marked increase in the concentrations of pregnenolone, progesterone and deoxycorticosterone in the brain cortex and hippocampus of handling-habituated rats. An accepted stress, such as foot shock, also enhanced the brain cortical levels of pregnenolone, progesterone and deoxycorticosterone in handling-habituated rats. These data show that the rat brain cortical and hippocampal steroid content is related to the 'emotional state' of the animal.
M L Barbaccia; G Roscetti; M Trabucchi; T Cuccheddu; A Concas; G Biggio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  261     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-02-09     Completed Date:  1995-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
Dipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Italy.
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MeSH Terms
Administration, Inhalation
Brain Chemistry / physiology*
Carbon Dioxide / administration & dosage,  pharmacology*
Cerebral Cortex / drug effects,  metabolism
Desoxycorticosterone / metabolism
Handling (Psychology)*
Hippocampus / drug effects,  metabolism
Pregnenolone / metabolism
Progesterone / metabolism
Rats, Sprague-Dawley
Steroids / metabolism*
Reg. No./Substance:
0/Steroids; 124-38-9/Carbon Dioxide; 145-13-1/Pregnenolone; 57-83-0/Progesterone; 64-85-7/Desoxycorticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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