| Neurospecific translation control and the problem of potent danger of drugs and chemicals: a caution. | |
| | |
MedLine Citation:
|
PMID: 2691419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
At present, chemicals are an integral part of the surrounding biosphere. A great number of new xenobiotics for industrial, pharmaceutical, agricultural, or mode-of-life daily use (perfumes, cosmetics, food additives, etc.) may play a role of a danger health hazards. These chemicals may be environmental pollutants and due to this circumstance they promote different ecological disorders including the several epidemic-like processes such as, for instance, Minamata disease (chronic alimentary poisoning with methyl mercury), etc. Also, these chemicals may be industrial hazards promoting the origin and development of various occupational diseases. Finally, the numerous side effects of multiple new drugs may serve as causes of a number of different health disorders. Briefly, we must agree that modern man exists in the world with such inalienable elements as the steadfast increase of chemical soiling of Earths biosphere. Naturally, human health protection in our "chemically soiled" world is very difficult by urgent task. As for the solving of this task, it may be reached only in the case of successful fundamental studies of mechanisms of toxic action of different classes of chemicals performed at different biological levels (systemic, organ/tissue, cellular and molecular levels of research). A separate and special population of modern health-hazardous chemicals is a group of agents which selectively suppress protein synthesis in mammalian cells and tissues due to the direct effect on the translation machinery elements or on the messenger RNA processing steps. The agents of this group ("translation blockers" or, the same but more broadly, "protein synthesis inhibitors" (PSI) usually are quite dangerous for human health since these substances inhibit the central molecular process of life, i.e., the synthesis of protein molecules. The small but important subclass of the PSI is represented by the agents with marked neurotropic properties, i.e., by the agents which are able to promote the effective inhibition of protein synthesis in the brain, while the same agents do not essentially influence the translation processes in the liver and all other organs of the animal (human) organism. The main aim of the present monograph is to review and analyze the data obtained recently in the course of biochemical research of several neurotropic PSI (methyl mercury, lithium salts). However, this is not the single aim of the book. Thus, besides this the present monograph deals with analysis of the general peculiarities of action of some non-neurotrophic inhibitors which are able, nevertheless, to direct a number of specific neurotrophic effects (Cordycepin, tRNA).(ABSTRACT TRUNCATED AT 400 WORDS) |
| | |
Authors:
|
D A Kuznetsov |
Related Documents
:
|
10810129 - Exposure biomarkers and risk from gluing and heating of polyurethane: a cross sectional... 7294269 - Choosing populations to study the health effects of low-dose ionizing radiation. 10812839 - Carcinogenicity and other health effects of acrylonitrile with reference to occupationa... 15214629 - Health effects of mycotoxins: a toxicological overview. 9432969 - A critique of the world resources institute's report "pesticides and the immune system:... 22521719 - Health literacy screening instruments for ehealth applications: a systematic review. 19705639 - Vulnerable categories of homeless patients in western societies: experience serious bar... 10159219 - An overview of the role of government in the organisation and provision of health servi... 10731239 - Future prospects of voluntary health insurance in thailand. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The International journal of neuroscience Volume: 49 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 1989 Nov |
Date Detail:
|
Created Date: 1990-02-12 Completed Date: 1990-02-12 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1-42 Citation Subset: IM |
Affiliation:
|
Moscow City Station for Sanitation and Epidemiology, Moscow, USSR. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Environmental Pollutants / toxicity* Humans Nerve Tissue Proteins / biosynthesis*, genetics Protein Biosynthesis / drug effects* Protein Synthesis Inhibitors / toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Environmental Pollutants; 0/Nerve Tissue Proteins; 0/Protein Synthesis Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The enigma of syndrome X.
Next Document: In vitro studies of interactions between frequent and unique mRNAs and cytoplasmic factors from brai...