| Neurosarcoidosis mimicking a malignant optic glioma. | |
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MedLine Citation:
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PMID: 18769287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 55-year-old African-American man developed progressive unilateral optic neuropathy and periocular pain. MRI showed thickening and enhancement of the mid-orbital segment of the ipsilateral optic nerve. Optic neuritis was diagnosed, and he was treated with corticosteroids without improvement. After being lost to follow-up, he returned with worsening vision in the affected eye, aggravated pain, and proptosis. MRI now showed thickening and enhancement of the entire orbital and intracranial segments of the optic nerve. Because the patient had no light perception vision in that eye and a malignant glioma was suspected, he underwent optic nerve biopsy that revealed non-caseating granulomas throughout the optic nerve tissue. CT body imaging failed to disclose other evidence of sarcoidosis. Neurosarcoidosis limited to the optic nerve is rare but should always be suspected in such circumstances. An exhaustive effort to find extracranial evidence for this diagnosis should be undertaken before resorting to optic nerve biopsy. |
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Authors:
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Jeffrey M Pollock; Francis G Greiner; Jason B Crowder; Jessica W Crowder; Eugene Quindlen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 28 ISSN: 1536-5166 ISO Abbreviation: J Neuroophthalmol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-04 Completed Date: 2009-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 214-6 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. jeffmpollock@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Diagnosis, Differential Diagnostic Errors / prevention & control Disease Progression Granuloma / pathology Humans Magnetic Resonance Imaging Male Middle Aged Optic Nerve / pathology* Optic Nerve Diseases / pathology* Optic Nerve Glioma / diagnosis* Orbit / pathology Sarcoidosis / pathology*, radiography Tomography, X-Ray Computed Vision, Low / etiology, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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