Document Detail

Neurorespiratory pattern of gill and lung ventilation in the decerebrate spontaneously breathing tadpole.
MedLine Citation:
PMID:  9832232     Owner:  NLM     Status:  MEDLINE    
A decerebrate, spontaneously breathing tadpole preparation (Taylor-Kollros stages 16-19) was used to test the general hypothesis that the efferent bursting activities of cranial nerves (CN) V, VII and spinal nerve (SN) II are respiratory in nature, and, in particular, to identify separate and specific neural correlates of gill and lung ventilation. Oropharyngeal pressure (POP), intrapulmonary pressure (PIP), electromyogram (EMG) of the buccal levator muscle (interhyoideus), and efferent neural activities of CN V, CN VII and SN II were recorded while the animal was exposed to hyperoxia (100% inspired O2), normoxia (21% inspired O2), and hypoxia (10, 5 and 0% inspired O2). Gill ventilation, indicated by fluctuations in POP at constant PIP, was characterized by high-frequency, low-amplitude bursts of action potentials in CN V and VII and interhyoideus EMG without phasic activity in SN II. Lung breaths, indicated by oscillations in POP and PIP were characterized by large bursts in EMG, CN V and VII together with a large burst in SN II. The amplitude of the moving average of nerve activities associated with lung ventilation was significantly larger than those associated with gill ventilation. During gill ventilation, the burst in CN V led that in CN VII, and both preceded the rise in POP. By contrast, a more synchronous neural burst onset pattern was observed during lung ventilation. The results document the neural, muscular, and mechanical characteristics of gill and lung ventilation in the tadpole, and establish bursting activity in SN II as a specific marker for lung ventilation in the metamorphic tadpole.
M J Gdovin; C S Torgerson; J E Remmers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  113     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-46     Citation Subset:  IM    
Division of Life Sciences, University of Texas at San Antonio, 78249, USA.
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MeSH Terms
Action Potentials / physiology
Cranial Nerves / physiology
Decerebrate State / physiopathology*
Gills / innervation*,  physiology*
Larva / physiology*
Lung / innervation*,  physiology*
Oropharynx / physiology
Pharyngeal Muscles / innervation,  physiology
Rana catesbeiana
Recruitment, Neurophysiological / physiology
Respiratory Mechanics / physiology*
Spinal Nerves / physiology

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