| Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders. A role for SNAP-25. | |
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MedLine Citation:
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PMID: 19713048 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Synaptosomal-associated protein of 25 KD (SNAP-25) is a protein that participates in synaptic vesicle exocytosis through the formation of a SNARE complex; SNAP-25 also plays a pivotal role in modulating calcium homeostasis through negative regulation of voltage-gated calcium channels. SNAP-25 has been involved in different neuropsychiatric disorders, including attention deficit hyperactivity disorder. There are well known physiological gender differences in many neuropsychological skills, and there are even more striking gender differences in patients with attention deficit hyperactivity disorder and autism spectrum disorders. We hypothesize that these differences are the result of a mechanism involving SNAP-25 polymorphisms and its differential expression in specific brain areas. |
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Authors:
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Alessandro Ghezzo; Franca R Guerini; Elisabetta Bolognesi; Michela Matteoli; Salvatorica Manca; Stefano Sotgiu; Maurizio Bejor; Mario Clerici; Matteo Chiappedi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-26 |
Journal Detail:
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Title: Medical hypotheses Volume: 73 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 978-80 Citation Subset: IM |
Affiliation:
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Don Carlo Gnocchi ONLUS Foundation, Centro Bignamini, Falconara, AN, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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