| Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. | |
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MedLine Citation:
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PMID: 10344633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropharmacological studies were conducted in experimental animals (rats and mice) with the methanolic fraction of Bryophyllum pinnatum leaf extract. The fraction produced alteration of behaviour pattern, caused dose-dependent potentiation of pentobarbitone sleeping time and had significant analgesic activity. Significant reduction of exploratory behaviour and loss of residual curiosity were among the effects observed with the fraction. The observations suggest that the methanolic fraction of Bryophyllum pinnatum possesses a potent CNS depressant action. |
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Authors:
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S Pal; T Sen; A K Chaudhuri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 51 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-07-28 Completed Date: 1999-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 313-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia Animals Anticonvulsants / pharmacology Behavior, Animal / drug effects* Brain Chemistry / drug effects Dose-Response Relationship, Drug Female Male Methanol / chemistry Mice Muscle Relaxation / drug effects Pentobarbital / pharmacology* Plant Extracts / pharmacology* Plant Leaves / chemistry Rats Sleep / drug effects* gamma-Aminobutyric Acid / analysis |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Plant Extracts; 56-12-2/gamma-Aminobutyric Acid; 67-56-1/Methanol; 76-74-4/Pentobarbital |
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