| Neuropsychopathology in the SIV/macaque model of AIDS. | |
| | |
MedLine Citation:
|
PMID: 15569612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Of the 40 million people living with HIV/AIDS worldwide in 2003, only 7% received highly active antiretroviral treatment (HAART). Without treatment, approximately half of AIDS patients will suffer from NeuroAIDS including neurological dysfunction, peripheral neuropathies, motor impairment, cognitive difficulties and frank dementia. HAART has reduced mortality from AIDS in the developed world, but CNS/neurological complications continue to be a leading cause of death or disability in AIDS patients on HAART. Despite years of use in developed countries, it is still not clear what the long-term impact of HAART will be on NeuroAIDS. The mechanisms of AIDS-related CNS pathology, in the presence or absence of HAART, are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent research model of AIDS, including AIDS-related CNS pathology and cognitive/behavioral impairments. A major goal of research with the SIV/macaque model has been to characterize behavioral and cognitive impairments in NeuroAIDS and elucidate the CNS pathology behind these impairments. Review of the studies assessing cognitive impairment in SIV infected macaques demonstrates the high concordance between neuropsychological impairment in human and simian AIDS. Consistent with results in human AIDS patients, SIV-infected monkeys tend to be impaired most often on tasks dependent upon intact frontal cortical and/or subcortical functioning. Building on the strengths of the SIV/macaque model of AIDS, directions for future research are discussed including further mechanistic studies of the neuropathology leading to cognitive impairment as well as assessment of the impact of antiretroviral therapy or drugs of abuse on NeuroAIDS. |
| | |
Authors:
|
Michael R Weed; David J Steward |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review Date: 2005-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 10 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2004-11-30 Completed Date: 2006-07-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 710-27 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. mweed@jhmi.edu <mweed@jhmi.edu> |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
AIDS Dementia Complex
/
drug therapy Acquired Immunodeficiency Syndrome / pathology*, virology* Animals Antiretroviral Therapy, Highly Active Cognition Disorders / drug therapy Disease Models, Animal Disease Progression Humans Macaca Models, Neurological Simian Acquired Immunodeficiency Syndrome / pathology*, virology* |
| Grant Support | |
ID/Acronym/Agency:
|
AA013794/AA/NIAAA NIH HHS; DA05831/DA/NIDA NIH HHS; DA10190/DA/NIDA NIH HHS; MH061189/MH/NIMH NIH HHS; T32 NS07392/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cell...
Next Document: Emerging roles of centrosomal amplification and genomic instability in cancer.