Document Detail

Neuropsychology of multiple sclerosis--an overview.
MedLine Citation:
PMID:  16477479     Owner:  NLM     Status:  MEDLINE    
Neuropsychological dysfunctions have been well documented in patients with multiple sclerosis. We herein give an overview of the main findings of recent decades. The pros and cons of considering the cognitive deficits of multiple sclerosis patients as a form of 'subcortical dementia' are discussed. By comparing the neuropsychological descriptions of multiple sclerosis patients as given in the literature to other neurological diseases which are also associated with neuropsychological deficiencies, we propose the term 'multiple disconnection syndrome' to describe the variety of neuropsychological deficits encountered in this demyelinating disease. Furthermore, a ' threshold of cerebral tolerance' is assumed which must be crossed before cognitive dysfunctions are manifested clinically.
Pasquale Calabrese
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neurology     Volume:  253 Suppl 1     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-14     Completed Date:  2006-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  I10-5     Citation Subset:  IM    
Dept. of Neurology, Knappschaftskrankenhaus, Neuropsychology Unit, Ruhr-University Bochum, In der Schornau 23-25, 44892, Bochum, Germany.
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MeSH Terms
Cognition / physiology
Memory / physiology
Mental Processes / physiology
Multiple Sclerosis / physiopathology*,  psychology*
Space Perception / physiology

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