Document Detail


Neuropsychological results and neuropathological findings at autopsy in a case of mild traumatic brain injury.
MedLine Citation:
PMID:  15327725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autopsy studies were undertaken in a 47-year-old college-educated male patient who, 7 months prior to an unexpected death, had sustained a mild traumatic brain injury (TBI) as manifested by brief loss of consciousness and an initial Glasgow Coma Scale score of 14. The patient died from cardiac arrest secondary to an undiagnosed and unknown arteriosclerotic cardiovascular disease as assessed by the coroners office at the time of autopsy. Gross inspection of the brain at autopsy was normal; however, microscopic analysis demonstrated what were considered trauma findings of hemosiderin-laden macrophages in the perivascular space and macrophages in the white matter, particularly the section taken from the frontal lobe. The patient had partially returned to work at the time of death, but had encountered problems with diminished cognitive performance in his work as an appraiser. Neuropsychological studies were generally within normal limits although several tests of either speed of processing or short-term memory showed lower than expected performance. This case demonstrates the presence of subtle neuropathological changes in the brain of a patient who sustained a mild TBI and was still symptomatic for the residual effects of the injury 7 months post injury when he unexpectedly died.
Authors:
Erin D Bigler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  10     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  794-806     Citation Subset:  IM    
Affiliation:
Departments of Psychology and Neuroscience, Brigham Young University, Provo, Utah 84602, USA. erin_bigler@byu.edu
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MeSH Terms
Descriptor/Qualifier:
Attention / physiology
Autopsy
Brain Injuries / pathology*,  physiopathology
Brain Mapping
Hemosiderin / metabolism
Histological Techniques / methods
Humans
Magnetic Resonance Imaging, Cine
Male
Memory / physiology
Middle Aged
Neurologic Examination
Neuropsychological Tests*
Personality Disorders
Postmortem Changes
Problem Solving / physiology
Chemical
Reg. No./Substance:
9011-92-1/Hemosiderin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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