| Neuropsychological profiles of adults with Klinefelter syndrome. | |
| | |
MedLine Citation:
|
PMID: 11396547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Children and adolescents with Klinefelter syndrome (XXY) have been reported to show deficits in language processing including VIQ < PIQ and a learning disability in reading and spelling. However, whether this is characteristic of adults with Klinefelter syndrome has not been established. Thirty-five men with Klinefelter syndrome, aged 16 to 61, and 22 controls were evaluated with a comprehensive neuropsychological battery. The Klinefelter patients scored significantly below controls in language skills, verbal processing speed, verbal and nonverbal executive abilities, and motor dexterity. Within the Klinefelter sample, three cognitive subgroups were identified: VIQ 7 or more points below PIQ (n = 10), VIQ within 6 points of PIQ (n = 12), and PIQ 7 or more points below VIQ (n = 12). The deficits detected in language, verbal processing speed, and verbal executive skills were found to be isolated to the VIQ < PIQ subgroup, while the abnormalities in motor dexterity and nonverbal executive skills were confined to the PIQ < VIQ subgroup. Older age was significantly correlated with increases in VIQ relative to PIQ in the patient group, which suggests the intriguing possibility that the PIQ < VIQ subgroup primarily emerges in young adulthood, perhaps in response to the reported hormonal abnormalities detected in Klinefelter syndrome patients during puberty. |
| | |
Authors:
|
K B Boone; R S Swerdloff; B L Miller; D H Geschwind; J Razani; A Lee; I G Gonzalo; A Haddal; K Rankin; P Lu; L Paul |
Related Documents
:
|
8071507 - Prader-willi syndrome. 14994977 - The diagnostic value of barium swallow in globus syndrome. 12784297 - Vocal cord abnormalities in williams syndrome: a further manifestation of elastin defic... 18839437 - A novel report of cig-fish and cytogenetics in poems syndrome. 22930247 - Common pathophysiological mechanisms involved in luteal phase deficiency and polycystic... 5024037 - Inosinic acid dehydrogenase activity in the lesch-nyhan syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the International Neuropsychological Society : JINS Volume: 7 ISSN: 1355-6177 ISO Abbreviation: J Int Neuropsychol Soc Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-06-08 Completed Date: 2001-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9503760 Medline TA: J Int Neuropsychol Soc Country: England |
Other Details:
|
Languages: eng Pagination: 446-56 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA. kboone@rei.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Cognition Disorders / diagnosis* Dyslexia / diagnosis Functional Laterality / physiology Humans Klinefelter Syndrome / genetics* Language Disorders / diagnosis Male Middle Aged Motor Skills Disorders / diagnosis Neuropsychological Tests Reaction Time Severity of Illness Index Verbal Behavior |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proton pump inhibitors and their drug interactions: an evidence-based approach.
Next Document: Use of the Disability Rating Scale Recovery curve as a predictor of psychosocial outcome following c...