Document Detail

Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia. Olfactory identification and Wisconsin Card Sorting performance.
MedLine Citation:
PMID:  1786234     Owner:  NLM     Status:  MEDLINE    
Schizophrenic patients and normal control subjects took the University of Pennsylvania Smell Identification Test (UPSIT) and Wisconsin Card Sorting Test (WCST) as dual neuropsychological 'probes' of orbitofrontal (OF) and dorsolateral (DL) prefrontal function respectively. Patients were significantly impaired on both tasks compared to controls. UPSIT and WCST performance were uncorrelated in patients but were positively correlated in controls. The lack of correlation found in the patients suggests that the tasks may be tapping independent dysfunctions in schizophrenia reflecting differential impairment in fronto-limbic brain systems. Individual profiles of preserved and impaired performance on the UPSIT and WCST suggested that three schizophrenic patients had OF dysfunction, five had DL dysfunction and seven had a generalized (OF and DL) frontal system dysfunction. The reduced ability of schizophrenic patients to identify odors was largely independent of many deficits or confounds typically associated with schizophrenia and did not appear to be simply a function of generalized deficit. These data are preliminary and require replication with larger samples and validation with other measures of fronto-limbic system dysfunction.
L J Seidman; N L Talbot; A G Kalinowski; R W McCarley; S V Faraone; W S Kremen; J R Pepple; M T Tsuang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia research     Volume:  6     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-26     Completed Date:  1992-03-26     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston 02115.
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MeSH Terms
Attention / physiology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis,  physiopathology*,  psychology*
Discrimination Learning / physiology*
Frontal Lobe / physiopathology*
Limbic System / physiopathology*
Middle Aged
Neuropsychological Tests*
Schizophrenia / diagnosis,  physiopathology*
Schizophrenic Psychology*
Smell / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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