Document Detail

Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances.
MedLine Citation:
PMID:  18327513     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: It has been hypothesized that people with subjective hypersensitivity to chemicals may indeed suffer from neuronal damage due to widely distributed environmental toxins and that such deficits of diagnostic importance can be demonstrated with the help of functional neuroimaging even in single cases. In this study, a small group of well-characterized patients with idiopathic environmental intolerance were examined in order to identify such changes. METHODS: Twelve patients with idiopathic environmental intolerance were investigated neuropsychologically and underwent cerebral F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET). The imaging results were compared with findings from 17 healthy controls. RESULTS: Six patients showed deficits in verbal learning and memory, three of them also had a reduced information processing speed. In the individual analyses, 11 patients showed normal cerebral glucose metabolism. In the group analysis of the patients, no areas with significantly reduced glucose metabolism could be found. CONCLUSIONS: No consistent pathological cognitive performance and functional imaging pattern was found. It appears premature to claim specific neuropsychological or neuroimaging findings characteristic of idiopathic environmental intolerance. Therefore cerebral F-18 FDG PET should not be used to corroborate or rule out suspected idiopathic environmental intolerance, a syndrome whose potential biological underpinnings still need to be clarified.
Susanne Bornschein; Constanze Hausteiner; Alexander Drzezga; Tina Theml; Barbara Heldmann; Timo Grimmer; Robert Perneczky; Thomas Jahn; Markus Schwaiger; Thomas Zilker; Hans Förstl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  33     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, Technical University (TU) of Munich, Klinikum rechts der Isar, Munich, Germany.
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MeSH Terms
Biological Markers
Brain / metabolism*
Cohort Studies
Fluorodeoxyglucose F18 / diagnostic use
Middle Aged
Multiple Chemical Sensitivity / psychology,  radionuclide imaging*
Neuropsychological Tests*
Positron-Emission Tomography*
Radiopharmaceuticals / diagnostic use
Reg. No./Substance:
0/Biological Markers; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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