Document Detail

Neuropsychological outcome in very young hematopoietic SCT recipients in relation to pretransplant conditioning.
MedLine Citation:
PMID:  18679374     Owner:  NLM     Status:  MEDLINE    
Stem cell transplantation involves conditioning with TBI and/or intensive chemotherapy, which may cause long-term neuropsychological deficits, particularly in children treated at a very young age. The aim of this study was to investigate whether very young children who receive chemotherapy-based conditioning only (BUCY) may have a more favorable neuropsychological outcome than children conditioned with TBI-CY. Twenty-two children who underwent allogeneic SCT at 0.4-3.6 years of age were subject to an extensive neuropsychological assessment at an average of 6.5 years post-therapy. The test results of 10 children exposed to BU were compared to the results of 12 children who had received TBI. Ten of them had received single-dose TBI, whereas two had received fractionated TBI. The BU group performed at age level on verbal measures, but tended to score below age level in the executive and visuo-spatial domains (P<0.01). By comparison, children treated with TBI had more pervasive neuropsychological impairments, including motor deficits (P<0.01) and varying degrees of perceptual (P<0.05), executive and cognitive (P<0.05) problems. In conclusion, children transplanted at a very young age had a more favorable neuropsychological development if conditioned with BUCY than if conditioned with single-dose TBI-CY.
A-C Smedler; J Winiarski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-04
Journal Detail:
Title:  Bone marrow transplantation     Volume:  42     ISSN:  1476-5365     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-22     Citation Subset:  IM    
Department of Psychology, Stockholm University, Stockholm, Sweden.
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MeSH Terms
Age Factors
Child, Preschool
Follow-Up Studies
Gait Disorders, Neurologic / epidemiology*,  etiology
Hematopoietic Stem Cell Transplantation / psychology*
Perceptual Disorders / epidemiology*,  etiology
Transplantation Conditioning / adverse effects*,  psychology
Transplantation, Homologous
Whole-Body Irradiation / adverse effects

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