Document Detail

Neuropsychological impairment in patients with schizophrenia and evidence of hyponatremia and polydipsia.
MedLine Citation:
PMID:  19413445     Owner:  NLM     Status:  MEDLINE    
Patients with schizophrenia and water imbalance may represent a subset of patients with distinct pathophysiological abnormalities and susceptibility to cognitive impairment. Specifically, patients with polydipsia and hyponatremia have been shown to have smaller anterior hippocampal volumes, which are also associated with various impairments in neuroendocrine function. To determine whether abnormalities in patients with water imbalance extend to the cognitive realm, the present study evaluated neuropsychological functioning in three groups of patients with schizophrenia: polydipsic hyponatremic, polydipsic normonatremic, and nonpolydipsic normonatremic. Participants were administered cognitive tests assessing intelligence, attention, learning/memory (verbal, nonverbal, emotional), and facial discrimination. Hyponatremic patients showed poorer overall neuropsychological functioning relative to all other patients, and polydipsic normonatremic patients performed intermediate to the other two groups. Results indicate that patients with schizophrenia and polydipsia, and particularly those with hyponatremia, show prominent cognitive deficits relative to patients without water imbalance. The clinical, neuroendocrine, and cognitive abnormalities in these patients may arise from pathology within the anterior hippocampus and associated prefrontal/limbic brain regions.
Ivan J Torres; Sarah Keedy; Megan Marlow-O'Connor; Beth Beenken; Morris B Goldman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychology     Volume:  23     ISSN:  0894-4105     ISO Abbreviation:  Neuropsychology     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904467     Medline TA:  Neuropsychology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
Department of Psychology, Simon Fraser University, Coquitlam, BC, Canada.
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MeSH Terms
Cognition Disorders / etiology,  psychology*
Discrimination Learning
Facial Expression
Hyponatremia / blood,  complications,  physiopathology*
Middle Aged
Neuropsychological Tests / statistics & numerical data
Psychiatric Status Rating Scales
Psychomotor Performance*
Schizophrenia / complications,  physiopathology*
Schizophrenic Psychology
Social Perception
Task Performance and Analysis
Verbal Learning
Grant Support

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