Document Detail

Neuropsychological function in manic-depressive psychosis. Evidence for persistent deficits in patients with chronic, severe illness.
MedLine Citation:
PMID:  7551609     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While neuropsychological deficits are recognised to occur in manic-depressive psychosis during episodes of depression and to reverse with clinical recovery, it is uncertain whether they can ever be seen outside episodes of illness. METHOD: Forty-five patients meeting DSM-III-R criteria for major depression or bipolar disorder were screened using tests of memory, executive function and overall intellectual function. All testing was carried out during remission of affective symptoms. RESULTS: None of 24 young patients and 11 elderly patients scored in the impaired range on any of the tests. However, five of ten patients with chronic, severe affective disorder were impaired on one or more of the measures. On more detailed neuropsychological investigation, these five patients were found to show a variable pattern of impairment, ranging from memory and executive deficits in relative isolation, to widespread poor performance. CONCLUSIONS: Enduring neuropsychological deficits may be a feature of chronic, severe manic-depressive illness.
A P McKay; A F Tarbuck; J Shapleske; P J McKenna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  167     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-21     Completed Date:  1995-11-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Fulbourn Hospital, Cambridge.
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MeSH Terms
Bipolar Disorder / diagnosis*,  psychology
Chronic Disease
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis*,  psychology
Depressive Disorder / diagnosis*,  psychology
Mental Recall
Mental Status Schedule
Middle Aged
Neuropsychological Tests*

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