| Neuropsychological and eye movement abnormalities in first-episode and chronic schizophrenia. | |
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MedLine Citation:
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PMID: 1621074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well known that neurobehavioral deficits are associated with schizophrenia. Little is known, however, about whether these disturbances becomes more severe over the course of the illness. In the present study, 101 patients with schizophrenia, of whom 45 were first-episode cases, performed pursuit eye tracking tasks. A subset of 60 of these patients, including 27 first-episode cases, were administered a battery of neuropsychological tests. Patients with a history of prior psychotic episodes demonstrated more severe pursuit eye movement dysfunction than first-episode patients and more severe disturbances on neuropsychological tests sensitive to prefrontal and left temporal cortical dysfunction. Longitudinal studies of patients ascertained close to the point of illness onset are needed to determine whether these findings reflect a progressive deterioration in neurobehavioral functioning over the course of schizophrenia. |
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Authors:
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J A Sweeney; G L Haas; S Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Schizophrenia bulletin Volume: 18 ISSN: 0586-7614 ISO Abbreviation: Schizophr Bull Publication Date: 1992 |
Date Detail:
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Created Date: 1992-08-06 Completed Date: 1992-08-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0236760 Medline TA: Schizophr Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-93 Citation Subset: IM |
Affiliation:
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Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / abnormalities, radiography Cross-Sectional Studies Eye Movements Female Frontal Lobe / abnormalities, physiopathology Functional Laterality Humans Longitudinal Studies Male Neuropsychological Tests Psychiatric Status Rating Scales Saccades Schizophrenia / diagnosis* Temporal Lobe / abnormalities, physiopathology Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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MHCRC-46745/MH/NIMH NIH HHS; R01-MH-42969/MH/NIMH NIH HHS; R29-MH-43613/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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