Document Detail

Neuropsychological dysfunction in schizophrenia and affective disease.
MedLine Citation:
PMID:  7272376     Owner:  NLM     Status:  MEDLINE    
We used Smith's neuropsychological test battery to study the cortical functioning of 52 patients with affective disorders, 17 schizophrenics, and 8 patients with coarse brain disease (CBD), all diagnosed according to research criteria. Testing and diagnoses were made independently and blindly. After accounting for the variance due to age, sex, handedness, educational level, and psychotropic drugs, we found that on tests of dominant hemisphere function schizophrenics performed significantly worse than patients with affective disorder but were no different from patients with CBD. On tests of nondominant hemisphere function the performance of the schizophrenics was similar to that of the other two groups, which were different from each other in that patients with CBD had poorer performance than affectives. A discriminant function analysis of the test scores applied to a jackknifed classification matrix successfully predicted research diagnosis in 86.5% of the affectively ill patients and 76.5% of the schizophrenics, for an overall hit rate of 84.1%. A canonical plot of the discriminant scores further showed distinct groups, with manics and depressives most alike but quite different from schizophrenics and patients with CBD. These findings are consistent with those derived from other neuropsychological studies, as well as EEG and CT scan studies.
M A Taylor; J Redfield; R Abrams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  16     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-78     Citation Subset:  IM    
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MeSH Terms
Affective Disorders, Psychotic / psychology*
Bipolar Disorder / diagnosis,  psychology*
Brain Damage, Chronic / diagnosis,  psychology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis,  psychology*
Depressive Disorder / diagnosis,  psychology*
Dominance, Cerebral
Middle Aged
Psychological Tests
Schizophrenia / diagnosis
Schizophrenic Psychology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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