| Neuropsychological changes in children with cancer: the treatment of missing data in longitudinal studies. | |
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MedLine Citation:
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PMID: 7881457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Researchers conducting longitudinal studies with children or adults are inevitably confronted with problems of attrition and missing data. Missing data in longitudinal studies is frequently handled by excluding from analyses those cases for whom data are incomplete. This approach to missing data is not optimal. On the one hand, if data are missing at random, then dropping incomplete cases ignores information collected on those cases that could be used to improve estimates of population parameters (e.g., means, variances, covariances, and growth rates) and improve the power of significance tests of statistical hypotheses. On the other hand, if data are not missing at random, then dropping incomplete cases leads to biased parameter estimates and hypothesis tests that may be internally and externally invalid. This study uses three years of follow-up data from a longitudinal investigation of neuropsychological outcomes of cancer in children to demonstrate the problems presented by missing data in repeated measures designs and some solutions. In evaluating potential biasing effects of attrition, the study extends previous research on neuropsychological outcomes in pediatric cancer by inclusion of patients whose disease had relapsed, and by comparison of surviving and nonsurviving patients. Although the data presented have specific relevance to the study of neuropsychological outcome in pediatric cancer, the problems of missing data and the solutions presented are relevant to a wide variety of diseases and conditions of interest to researchers in child and adult neuropsychology. |
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Authors:
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D J Francis; D R Copeland; B D Moore |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Neuropsychology review Volume: 4 ISSN: 1040-7308 ISO Abbreviation: Neuropsychol Rev Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9009029 Medline TA: Neuropsychol Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-222 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Houston, Texas 77204-5341. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Bias (Epidemiology) Child Child, Preschool Follow-Up Studies Hodgkin Disease / diagnosis Humans Leukemia / diagnosis Longitudinal Studies Models, Statistical Neoplasms / diagnosis*, psychology Neuropsychological Tests / statistics & numerical data* Osteosarcoma / diagnosis Recurrence Research Design / standards* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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CA-33097/CA/NCI NIH HHS; HD 28172/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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