Document Detail


Neuropsychological assessment of patients with dementing illness.
MedLine Citation:
PMID:  22045270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropsychological assessment has a distinct role in the detection and monitoring of cognitive and functional changes associated with dementing illness. Molecular, structural and functional neuroimaging studies have advanced our understanding of the anatomy and physiology underlying neurodegenerative disease; however, the overlap in pathological features of different dementia-associated diseases limits the information that can be obtained by these methods. Incorporation of information obtained from multiple sources can help to increase diagnostic and prognostic accuracy. Neuropsychological test findings provide unique value as biomarkers of dementia, as differentiators of disease topography and in the estimation of disease risk and trajectory. However, psychometric test properties--such as construct validity, stability and the use of appropriate norms--must be understood, because they influence both the application of neuropsychological tests and the interpretation of their results. Finally, measurement of cognitive strengths and weaknesses in patients at risk of dementia can be helpful to predict changes in functional abilities, design appropriate and effective interventions, and assist family and health-care providers in the planning of the patient's future care needs. This Review describes the key characteristics of neuropsychological testing in the assessment of patients at risk of dementia.
Authors:
Julie A Fields; Tanis J Ferman; Bradley F Boeve; Glenn E Smith
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-11-01
Journal Detail:
Title:  Nature reviews. Neurology     Volume:  7     ISSN:  1759-4766     ISO Abbreviation:  Nat Rev Neurol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  2012-08-21     Revised Date:  2013-12-17    
Medline Journal Info:
Nlm Unique ID:  101500072     Medline TA:  Nat Rev Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  677-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cognition Disorders / blood,  diagnosis,  psychology
Dementia / blood,  diagnosis*,  psychology*
Functional Neuroimaging / methods
Humans
Neuropsychological Tests* / standards
Grant Support
ID/Acronym/Agency:
1K12HD065987/HD/NICHD NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG16574/AG/NIA NIH HHS; R01 AG15866/AG/NIA NIH HHS; R01 NR12419/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers

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