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Neuropsychiatric features of a cohort of patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  23227358     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In order to establish if neuropsychiatric systemic lupus erythematosus (NPSLE) can be identified by any characteristic other than those used to diagnose the neuropsychiatric (NP) disease itself, we retrospectively reviewed 98 systemic lupus erythematosus (SLE) patients followed over a mean period of 10 years. NPSLE was identified in 22 patients. Stroke and generalized seizures were the most frequent NP manifestations. The NPSLE and non-NPSLE groups were similar with regard to demographic characteristics, ACR criteria, serum autoantibodies, and frequency of hypertension and hypercholesterolemia. Of note, compared to the non-NPSLE group, NPSLE was associated with a higher frequency of smoking (78 versus 26%), organ damage (73 versus 34%), and cumulative mortality rate (14 versus 7%). The series of patients was further analysed according to the presence of antiphospholipid syndrome (APS). Significantly, the interval between the onset of NP disease and SLE diagnosis was shorter in the APS(-) (0.3 ± 1 years) than in the APS(+) (5 ± 7 years) groups. Recurrence and/or persistence of NP events were only documented in the APS(-) group. Overall cumulative mortality was highest in NPSLE and in APS(+) patients with inadequate anticoagulation control, identifying an aspect that requires improved vigilance and the development of novel therapeutic modalities.
Authors:
Maria Francisca Moraes-Fontes; Isabel Lúcio; Céu Santos; Maria Manuel Campos; Nuno Riso; Manuel Vaz Riscado
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Publication Detail:
Type:  Journal Article     Date:  2012-11-20
Journal Detail:
Title:  ISRN rheumatology     Volume:  2012     ISSN:  2090-5475     ISO Abbreviation:  ISRN Rheumatol     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2012-12-12     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  101570649     Medline TA:  ISRN Rheumatol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  989218     Citation Subset:  -    
Affiliation:
Unidade de Doenças Auto-Imunes, Serviço 2-Medicina Interna, Hospital Curry Cabral, Centro Hospitalar Lisboa Central, Portugal.
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