| Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 19946864 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH). METHODS: Thirty-seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI-based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes. RESULTS: Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD. CONCLUSIONS: These findings suggest that white matter changes are associated with the presence of BPSD in AD. |
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Authors:
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Yosef A Berlow; William M Wells; James M Ellison; Young Hoon Sung; Perry F Renshaw; David G Harper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: International journal of geriatric psychiatry Volume: 25 ISSN: 1099-1166 ISO Abbreviation: Int J Geriatr Psychiatry Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710629 Medline TA: Int J Geriatr Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 780-8 Citation Subset: IM |
Affiliation:
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Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 AG020654/AG/NIA NIH HHS |
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