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Neuroproteomics: an insight into ALS.
MedLine Citation:
PMID:  23146297     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown aetiology. Diagnosis is made through physical examination, electrophysiological findings, and by excluding other conditions. There is not a single biomarker that concludes the diagnosis. The aim of this study was to investigate differentially expressed proteins in cerebrospinal fluid (CSF) of ALS patients compared to control subjects, with the purpose to identify a panel of possible biomarkers for the disease. The differentially expressed spots/proteins were submitted to two-dimensional (2D) electrophoresis and recognized with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry. Parkin-like and many iron and zinc binding were some of the proteins found in ALS CSF. Parkin is a ligase involved in ubiquitin-proteasome pathway and mutations in the parkin gene are the most common cause of recessive familial Parkinson's disease. Iron and zinc are involved with many important metabolic processes and are related to neurodegenerative disease. Common features of ALS comprise failure of the ubiquitin-proteasome system and increased levels of metal ions in the brain. Therefore, the identification of these proteins can be a significant step in ALS research. These and other identified proteins are discussed in this study.
Authors:
D M F Mendonça; L Pizzati; K Mostacada; S C de S Martins; R Higashi; L Ayres Sá; V Moura Neto; L Chimelli; A M B Martinez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  34     ISSN:  1743-1328     ISO Abbreviation:  Neurol. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  937-43     Citation Subset:  IM    
Affiliation:
Universidade Federal de Sergipe, Brazil.
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