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Neuroprotective treatment of cerebral infarction: an experimental study.
MedLine Citation:
PMID:  23126386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract We investigated the effect of the amniotic-derived peptide Plaferon-LB on cerebral tissue damage during photochemical insults in rats. Plaferon-LB (US patent number: 20070123467 A1) was extracted from the amniochorionic membrane of a human placenta and showed a relatively strong anti-hypoxic effect compared to other interferon. Thrombotic infarction was induced by photochemical illumination after intravenous injection of Rose Bengal. The infarct volume, cerebral tissue oxygen tension, cerebral blood flow, and capillary damage were measured in the following groups: untreated control rats, Plaferon-LB-alone rats, insult-alone rats, and insult in Plaferon-LB pre-treated rats. The technique of Electron Paramagnetic Resonance EPR spectroscopy was used to study free-radical metabolites in the blood and brain tissue ex vivo. Plaferon-LB alone had no effect on systemic blood pressure, cerebral blood flow and reactive metabolites in the brains of intact animals. In the insult-alone group, a focal haemorrhage was observed in the ischemic area. The cerebral blood flow and tissue oxygen pressure declined to zero within an hour and remained at this level throughout the insult. The treatment with Plaferon-LB 0.5 h before illumination resulted in a significant reduction of the median infarct size in the insult-alone group. The total length and percentage ratio of thrombotic vessels were significantly diminished in the infarct area. The intensity of Fe(2+),Mn(2+)- Mo(5+)-xanthinoxidase-containing complexes and NO EPR signals were decreased, and the electron transport in the mitochondria was normalised. The results indicate a significant beneficial effect of Plaferon-LB on cerebral infarct, which is likely due to its anti-oxidative properties.
Authors:
Tamar V Sanikidze; Maia Beridze; Nodar Mitagvaria; Sophia Bakhtadze; Nadeem Khan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  The International journal of neuroscience     Volume:  -     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Tbilisi State Medical University, Vaja Pshavela Avenue 33 , Tbilisi, 0177 , Georgia.
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