| Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy. | |
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MedLine Citation:
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PMID: 17571357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurodegeneration in limbic circuits is a hallmark feature of chronic temporal lobe epilepsy (TLE). Studies in experimental animal models and human patients indicate that seizure-induced neuronal injury involves some active, as well as passive cell death processes. Experimental approaches that inhibit active steps in cell death programs have been shown to reduce neuronal cell death and sclerosis, but not to prevent epileptogenesis in animal models of TLE. These findings suggest that we need additional research using both animal models and brain slices from human patients to understand the pathological mechanisms underlying seizure generation. Such comparative studies will also aid in evaluating the potential therapeutic value of inhibiting cell death in seizure disorders. |
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Authors:
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Janice R Naegele |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Epilepsia Volume: 48 Suppl 2 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2007 |
Date Detail:
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Created Date: 2007-06-15 Completed Date: 2007-07-17 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 107-17 Citation Subset: IM |
Affiliation:
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Department of Biology, Room 257, Hall-Atwater Laboratory, Lawn Avenue, Wesleyan University, Middletown, CT 06459, USA. janaegele@wesleyan.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology, physiopathology Calcium / physiology Cell Death / physiology DNA Damage / physiology DNA Repair / physiology Disease Models, Animal* Epilepsy, Temporal Lobe / pathology, physiopathology*, therapy* Gene Therapy Genes, bcl-1 / physiology Humans Models, Neurological Nerve Degeneration / physiopathology, prevention & control* Neuroprotective Agents / therapeutic use* Rats Research Design Seizures* / pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS042826-05/NS/NINDS NIH HHS; R01 NS42826/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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