| Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 19804785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Chronic hyperglycaemia in diabetes involves a direct neuronal damage caused by intracellular glucose which leads to altered neurotransmitter functions and reduced motor activity. The present study investigated the effect of curcumin in the functional regulation of muscarinic and alpha7 nicotinic acetylcholine receptors, insulin receptors, acetylcholine esterase and Glut3 in the cerebellum of streptozotocin (STZ)-induced diabetic rats. MAIN METHODS: All studies were done in the cerebellum of male Wistar rats. Radioreceptor binding assays were done for total muscarinic, M(1) and M(3) receptors using specific ligands, and the gene expression was also studied using specific probes. KEY FINDINGS: Our results showed an increased gene expression of acetylcholine esterase, Glut3, muscarinic M1, M3, alpha7 nicotinic acetylcholine and insulin receptors in the cerebellum of diabetic rats in comparison to control. Scatchard analysis of total muscarinic, M1 and M3 receptors showed an increased binding parameter, B(max) in diabetic rats compared to control. Curcumin and insulin inhibited diabetes-induced elevation in the gene expression of acetylcholine esterase, Glut3, insulin and cholinergic receptors in the cerebellum of diabetic rats. SIGNIFICANCE: Our studies suggest that curcumin plays a vital role in regulating the activity of cholinergic and insulin receptors and mechanism of glucose transportation through Glut3, which results in normalizing the diabetes-mediated cerebellar disorders. Thus, curcumin has a significant role in a therapeutic application for the prevention or progression of diabetic complications in the cerebellum. |
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Authors:
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Kumar T Peeyush; G Gireesh; Mathew Jobin; C S Paulose |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-03 |
Journal Detail:
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Title: Life sciences Volume: 85 ISSN: 1879-0631 ISO Abbreviation: Life Sci. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-11-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 704-10 Citation Subset: IM |
Affiliation:
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Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Cochin University of Science and Technology, Cochin - 682 022, Kerala, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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biosynthesis Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Blood Glucose / metabolism Cerebellum / pathology* Curcumin / pharmacology* Diabetes Mellitus, Experimental / pathology* Glucose Transporter Type 3 / biosynthesis, genetics Kinetics Male Neuroprotective Agents* Postural Balance / drug effects Rats Rats, Wistar Receptor, Insulin / drug effects Receptor, Muscarinic M1 / drug effects Receptor, Muscarinic M3 / drug effects Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Blood Glucose; 0/Glucose Transporter Type 3; 0/Neuroprotective Agents; 0/Receptor, Muscarinic M1; 0/Receptor, Muscarinic M3; 0/Slc2a3 protein, rat; 458-37-7/Curcumin; EC 2.7.10.1/Receptor, Insulin; EC 3.1.1.7/Acetylcholinesterase |
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