| Neuroprotective fractalkine in fetal alcohol syndrome. | |
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MedLine Citation:
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PMID: 21572545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Neuroprotective peptides (NAP+SAL) can prevent some alcohol-induced damage in fetal alcohol syndrome(FAS). Fractalkine, a chemokine constitutively expressed in the CNS reduces neuronal death from activated microglia. Using a model of FAS we evaluated if fractalkine is altered and if NAP+SAL work through fractalkine. STUDY DESIGN: Using a FAS model, C57BL6/J-mice were treated on gestational day 8 with alcohol (0.03 mL/g), placebo or alcohol+peptides. Embryos were harvested after 6h(E8) and 10 days later(E18). Fractalkine was measured in the protein lysate (Luminex xMAP). Statistical analysis included Kruskal-Wallis. RESULTS: Fractalkine was significantly elevated at 6h (median 341 pg/ml, range 263-424 pg/ml) vs. controls (median 228 pg/ml, range 146-332 pg/ml; P<.001). NAP+SAL prevented the alcohol-induced increase (median 137, range 97-255 pg/ml, P<.001). At E18, fractalkine levels were similar in all groups (P=0.7). CONCLUSION: Prenatal alcohol exposure acutely elevates fractalkine, perhaps in an effort to counter the alcohol toxicity. Pre-treatment with NAP+SAL prevents the acute increase in fractalkine. |
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Authors:
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Robin Roberson; Thea Kuddo; Ines Benassou; Daniel Abebe; Catherine Spong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 204 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-07-26 Completed Date: 2011-10-07 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 400.e1-3 Citation Subset: AIM; IM |
Affiliation:
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Unit on Perinatal and Developmental Neurobiology, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. robersor@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemokine CX3CL1 / metabolism* Disease Models, Animal Ethanol / administration & dosage* Female Fetal Alcohol Syndrome / metabolism* Mice Microglia / metabolism Nerve Tissue Proteins / administration & dosage Oligopeptides / administration & dosage Peptide Fragments / administration & dosage Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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Z99 HD999999/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CX3CL1; 0/NAPVSIPQ peptide; 0/Nerve Tissue Proteins; 0/Oligopeptides; 0/Peptide Fragments; 0/SALLRSIPA; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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