| Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells. | |
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MedLine Citation:
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PMID: 17321170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we investigated the effects of tetramethylpyrazine (TMP) on hydrogen peroxide (H2O2)-induced apoptosis in PC12 cells. The apoptosis in H2O2-induced PC12 cells was accompanied by a decrease in Bcl-2/Bax protein ratio, release of cytochrome c to cytosol and the activation of caspase-3. TMP not only suppressed the down-regulation of Bcl-2, up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol, but also attenuated caspase-3 activation and eventually protected against H2O2-induced apoptosis. These results indicated that TMP blocked H2O2-induced apoptosis by the regulation of Bcl-2 family members, suppression of cytochrome c release, and caspase cascade activation in PC12 cells. |
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Authors:
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Xin-Rui Cheng; Li Zhang; Juan-Juan Hu; Lan Sun; Guan-Hua Du |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-18 |
Journal Detail:
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Title: Cell biology international Volume: 31 ISSN: 1065-6995 ISO Abbreviation: Cell Biol. Int. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 438-43 Citation Subset: IM |
Affiliation:
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National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 XianNongTan Street, Beijing 100050, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects* Caspase 3 / metabolism Caspase 8 / metabolism Cell Survival / drug effects Cytochromes c / drug effects, metabolism Hydrogen Peroxide / toxicity* Neuroprotective Agents / pharmacology* PC12 Cells Pheochromocytoma Pyrazines / pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Pyrazines; 1124-11-4/tetramethylpyrazine; 7722-84-1/Hydrogen Peroxide; 9007-43-6/Cytochromes c; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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