Document Detail

Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia.
MedLine Citation:
PMID:  16867245     Owner:  NLM     Status:  MEDLINE    
AIM: To observe neuroprotective effects of raw and roasted licorice against hypoxia and ischemic damage. METHODS: When elucidating the protective effects of raw and roasted licorice, we analyzed the lactate dehydrogenase (LDH) release using PC12 cells after hypoxia in an in vitro study and after transient forebrain ischemia in an in vivo study on Mongolian gerbils. RESULTS: Raw and roasted licorice significantly reduced LDH release from PC12 cells exposed to an hypoxic chamber for 1 h. In the roasted licorice-treated group, the decrease of LDH release was more pronounced compared to that of the raw licorice-treated group. In roasted licorice-treated animals, approximately 66%-71% of CA1 pyramidal cells in the ischemic hippocampus were stained with cresyl violet compared to the control group. However, in the raw licorice-treated animals, no significant neuroprotection against ischemic damage was shown. In addition, ischemic animals in roasted licorice-treated group maintained the Cu, Zn-superoxide dismutase (SOD1) activity and protein levels compared to the control group, while in raw licorice-treated group SOD1 activity and protein levels were reduced significantly. High pressure liquid chromatography analysis showed that non-polar compounds containing glycyrrhizin-degraded products, such as glycyrrhetinic acid (GA) and glycyrrhetinic acid monoglucuronide (GM), were increased in roasted licorice. CONCLUSION: Roasted licorice had neuroprotective effects against ischemic damage by maintaining the SOD1 levels. In addition, the difference in protective ability between raw and roasted licorice may be associated with non-polar compounds, such as GA and GM.
In-Koo Hwang; Soon-Sung Lim; Kyu-Hyun Choi; Ki-Yeon Yoo; Hyun-Kyung Shin; Eun-Ji Kim; Jung-Han Yoon-Park; Tae-Cheon Kang; Young-Sup Kim; Dae-Young Kwon; Dong-Woo Kim; Won-Kook Moon; Moo-Ho Won
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  27     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-26     Completed Date:  2007-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  959-65     Citation Subset:  IM    
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, Korea.
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MeSH Terms
Cell Hypoxia
Drugs, Chinese Herbal / isolation & purification,  pharmacology*
Glycyrrhiza* / chemistry
Hippocampus / metabolism,  pathology
Ischemic Attack, Transient / metabolism*,  pathology
L-Lactate Dehydrogenase / metabolism
Neuroprotective Agents / isolation & purification,  pharmacology*
PC12 Cells
Plants, Medicinal / chemistry
Pyramidal Cells / drug effects
Superoxide Dismutase / metabolism*
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Neuroprotective Agents; EC Dehydrogenase; EC 1.15.1.-/superoxide dismutase 1; EC Dismutase

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