| Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. | |
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MedLine Citation:
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PMID: 21375602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The protective impact of exercise on neurodegenerative processes has not been confirmed, and the mechanisms underlying the benefit of exercise have not been determined in human Parkinson's disease or in chronic animal disease models. This research examined the long-term neurological, behavioral, and mechanistic consequences of endurance exercise in experimental chronic parkinsonism. We used a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease with moderate neurodegeneration and examined the effects of treadmill exercise on movement and balance coordination, changes in dopamine neuron biomarkers, mitochondrial functions, and neurotrophic factor activities in the nigrostriatal system. The exercise results were compared with those of the control and sedentary chronic parkinsonian animals. After 18 weeks of exercise training in the chronic parkinsonian mice, we observed a significant deterrence in the loss of neuronal dopamine-producing cells and other functional indicators. The impaired movement and balance incoordination in the chronic parkinsonian mice were also markedly reduced following exercise. Mechanistic investigations revealed that the neuronal and behavioral recovery produced by exercise in the chronic parkinsonian mice was associated with an improved mitochondrial function and an increase in the brain region-specific levels of brain-derived and glial cell line-derived neurotrophic factors. Our findings indicate that exercise not only produces neuronal and mitochondrial protection, it also boosts nigrostriatal neurotrophic factor levels in the chronic parkinsonian mice with moderate neurodegeneration. Therefore, modifying lifestyle with increased exercise activity would be a non-pharmacological neuroprotective approach for averting neurodegenerative processes, as demonstrated in experimental chronic parkinsonism. |
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Authors:
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Yuen-Sum Lau; Gaurav Patki; Kaberi Das-Panja; Wei-Dong Le; S Omar Ahmad |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-07 |
Journal Detail:
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Title: The European journal of neuroscience Volume: 33 ISSN: 1460-9568 ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-07-18 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 1264-74 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. |
Affiliation:
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Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA. ylau2@uh.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Pharmaceutic
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pharmacology Animals Biological Markers / metabolism Brain-Derived Neurotrophic Factor / metabolism Corpus Striatum / cytology, metabolism Disease Models, Animal* Dopamine / metabolism Exercise Glial Cell Line-Derived Neurotrophic Factors / metabolism Humans Male Mice Mice, Inbred C57BL Mitochondria / metabolism Motor Activity / physiology Nerve Degeneration / pathology* Neurons / cytology, metabolism Parkinson Disease / pathology, physiopathology Parkinsonian Disorders / pathology*, physiopathology* Physical Conditioning, Animal* Probenecid / pharmacology Substantia Nigra / cytology, metabolism Superoxide Dismutase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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NS 47920/NS/NINDS NIH HHS; R01 NS047920-01/NS/NINDS NIH HHS; R01 NS047920-01S1/NS/NINDS NIH HHS; R01 NS047920-02/NS/NINDS NIH HHS; R01 NS047920-03/NS/NINDS NIH HHS; R01 NS047920-04/NS/NINDS NIH HHS; R01 NS047920-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Pharmaceutic; 0/Biological Markers; 0/Brain-Derived Neurotrophic Factor; 0/Glial Cell Line-Derived Neurotrophic Factors; 57-66-9/Probenecid; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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