| Neuroprotective effects of estrogens following ischemic stroke. | |
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MedLine Citation:
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PMID: 19401209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our laboratory has investigated whether and how 17beta-estradiol (E(2)) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E(2), which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E(2). Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations. |
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Authors:
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Shotaro Suzuki; Candice M Brown; Phyllis M Wise |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-05-03 |
Journal Detail:
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Title: Frontiers in neuroendocrinology Volume: 30 ISSN: 1095-6808 ISO Abbreviation: Front Neuroendocrinol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-23 Completed Date: 2009-08-17 Revised Date: 2011-04-21 |
Medline Journal Info:
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Nlm Unique ID: 7513292 Medline TA: Front Neuroendocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 201-11 Citation Subset: IM |
Affiliation:
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Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195-1237, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents* / metabolism, pharmacology, therapeutic use Brain Ischemia / drug therapy*, pathology Estrogen Receptor alpha / metabolism Estrogen Replacement Therapy Estrogens* / metabolism, pharmacology, therapeutic use Hippocampus / cytology, growth & development Humans Inflammation / metabolism Nerve Growth Factors / metabolism Nerve Regeneration / drug effects Neurogenesis / drug effects Neuroprotective Agents* / metabolism, pharmacology, therapeutic use Receptors, Glutamate / metabolism Stroke / drug therapy*, pathology, prevention & control |
| Grant Support | |
ID/Acronym/Agency:
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AG 27614/AG/NIA NIH HHS; AG02224/AG/NIA NIH HHS; AG17164/AG/NIA NIH HHS; F32 AG027614-02/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Estrogen Receptor alpha; 0/Estrogens; 0/Nerve Growth Factors; 0/Neuroprotective Agents; 0/Receptors, Glutamate; 0/estrogen receptor alpha, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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