Document Detail

Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia.
MedLine Citation:
PMID:  16181734     Owner:  NLM     Status:  MEDLINE    
This study investigated the neuroprotective effects of cyanidin-3-O-beta-d-glucopyranoside (C3G) from the mulberry fruits on neuronal cell damage. A 1% HCl-MeOH mulberry fruit extract was shown to have a cytoprotective effect on PC12 cells that had been exposed to hydrogen peroxide. The extract inhibited the cerebral ischemic damage caused by oxygen glucose deprivation (OGD) in PC12 cells. The neuroprotective effect of the mulberry fruit extract was further demonstrated in vivo using a mouse-brain-injury model with a transient middle cerebral artery occlusion (MCAO). C3G was isolated as a neuroprotective constituent from the mulberry fruit extract. Compared with the control group, C3G had neuroprotective effects on the PC12 cells exposed to hydrogen peroxide in vitro and on cerebral ischemic damage in vivo.
Tong Ho Kang; Jin Young Hur; Hyun Bok Kim; Jong Hoon Ryu; Sun Yeou Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-19
Journal Detail:
Title:  Neuroscience letters     Volume:  391     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Graduate School of East-West Medical Science, Kyunghee University, Kyunggi 449-701, South Korea.
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MeSH Terms
Anthocyanins / administration & dosage*
Brain Ischemia / pathology*,  prevention & control*
Dose-Response Relationship, Drug
Fruit / chemistry*
Mice, Inbred ICR
Morus / chemistry*
Neuroprotective Agents / administration & dosage*
PC12 Cells
Plant Extracts / administration & dosage
Reg. No./Substance:
0/Anthocyanins; 0/Neuroprotective Agents; 0/Plant Extracts; 0/cyanidin-3-O-beta-glucopyranoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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