Document Detail

Neuroprotective effects of constituents of Eragrostis ferruginea against Abeta-induced toxicity in PC12 cells.
MedLine Citation:
PMID:  20661708     Owner:  NLM     Status:  In-Process    
A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Abeta) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED(50) value of 20.3 microM against Abeta-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED(50) values of 58.7, 44.1, and 54.8 microM, respectively.
Chae Sun Na; Seong Su Hong; Yun-Hyeok Choi; Yong Ho Lee; Sun Hee Hong; Ji-Youn Lim; Byeong Hoa Kang; So-Young Park; Dongho Lee
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-07-27
Journal Detail:
Title:  Archives of pharmacal research     Volume:  33     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  999-1003     Citation Subset:  IM    
Korea University, Seoul, Korea.
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