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Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.
MedLine Citation:
PMID:  25481089     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Parkinson disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic neurodegeneration, mitochondrial impairment, and oxidative stress. Exposure of animals to rotenone induces a range of responses characteristics of PD, including reactive oxygen species production and dopaminergic cell death. Although l-dopa is the drug of choice for improving core symptoms of PD, it is associated with involuntary movements. The current study was directed to evaluate the neuroprotective effect of bee venom acupuncture therapy (BVA) against rotenone-induced oxidative stress, neuroinflammation, and apoptosis in PD mouse model. Forty male Swiss mice were divided into four groups; (1): received saline solution orally and served as normal control, (2): received rotenone (1.5 mg/kg, s.c, everyother day for 6 doses), (3): received rotenone concomitantly with l-dopa (25 mg/kg, daily, p.o, for 6 days), and finally (4): received rotenone concomitantly with BVA (0.02 ml once every 3 days for two weeks). Rotenone-treated mice showed impairment in locomotor behavior and a significant reduction in brain dopamine, serotonin, norepinephrine, GSH levels, and paraoxonase activity. Whereas a significant increase was observed in brain malondialdehyde, tumor necrosis factor-α, interleukin-β levels besides DNA damage, and over-expression of caspase-3, Bax, and Bcl-2 genes. Significant improvement of the aforementioned parameters was demonstrated after BVA compared to l-dopa therapy. In conclusion, bee venom normalized all the neuroinflammatory and apoptotic markers and restored brain neurochemistry after rotenone injury. Therefore, BVA is a promising neuroprotective therapy for PD.
Authors:
Wagdy K B Khalil; Naglaa Assaf; Shaimaa A ElShebiney; Neveen A Salem
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-3
Journal Detail:
Title:  Neurochemistry international     Volume:  -     ISSN:  1872-9754     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-7     Completed Date:  -     Revised Date:  2014-12-8    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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