Document Detail


Neuroprotective effects of the antiparkinson drug Mucuna pruriens.
MedLine Citation:
PMID:  15478206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q-10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-I activity and the presence of NADH and coenzyme Q-10.
Authors:
Bala V Manyam; Muralikrishnan Dhanasekaran; Theodore A Hare
Related Documents :
15478206 - Neuroprotective effects of the antiparkinson drug mucuna pruriens.
2563976 - Expression of the mutant gene for l-gulono-gamma-lactone oxidase in scurvy-prone rats.
12676606 - Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and r...
8627306 - Identification and determination of 3,4-dihydroxyphenylacetaldehyde, the dopamine metab...
6204946 - Inhibition of anaphylactic histamine release and pulmonary distress in rats by nonspeci...
3843736 - A deficit in ambient visual guidance following superior colliculus lesions in rats.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  706-12     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 John Wiley & Sons, Ltd.
Affiliation:
Department of Neurology, Health Science Center College of Medicine, Temple, TX 76508, USA. bmanyam@swmail.sw.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Levodopa / administration & dosage,  pharmacology,  therapeutic use
Male
Mitochondria / drug effects,  metabolism
Mucuna*
Neuroprotective Agents / administration & dosage,  pharmacology*,  therapeutic use
Oxidopamine / diagnostic use
Parkinson Disease / drug therapy*,  pathology
Phytotherapy*
Plant Components, Aerial
Random Allocation
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
RFA 00-93-002//PHS HHS
Chemical
Reg. No./Substance:
0/Levodopa; 0/Neuroprotective Agents; 1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reversal of LPS-induced immobility in mice by green tea polyphenols: possible COX-2 mechanism.
Next Document:  The chemical composition of some Lauraceae essential oils and their antifungal activities.