Document Detail

Neuroprotective effects of the antiparkinson drug Mucuna pruriens.
MedLine Citation:
PMID:  15478206     Owner:  NLM     Status:  MEDLINE    
Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q-10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-I activity and the presence of NADH and coenzyme Q-10.
Bala V Manyam; Muralikrishnan Dhanasekaran; Theodore A Hare
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  706-12     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 John Wiley & Sons, Ltd.
Department of Neurology, Health Science Center College of Medicine, Temple, TX 76508, USA.
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MeSH Terms
Dose-Response Relationship, Drug
Levodopa / administration & dosage,  pharmacology,  therapeutic use
Mitochondria / drug effects,  metabolism
Neuroprotective Agents / administration & dosage,  pharmacology*,  therapeutic use
Oxidopamine / diagnostic use
Parkinson Disease / drug therapy*,  pathology
Plant Components, Aerial
Random Allocation
Rats, Sprague-Dawley
Grant Support
RFA 00-93-002//PHS HHS
Reg. No./Substance:
0/Levodopa; 0/Neuroprotective Agents; 1199-18-4/Oxidopamine

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