| Neuroprotective effects of almond skins in experimental spinal cord injury. | |
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MedLine Citation:
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PMID: 20864228 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Functional deficits following spinal cord injury (SCI) arise from both mechanical injury and from secondary tissue reactions involving inflammation. Natural almond skins (NS) were tested to evaluate anti-inflammatory effects on an animal model of SCI. METHODS: SCI was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. In the present study, to elucidate whether the protective effects of NS are related to the total phenolic content, we also investigated the effect of a blanched (BS) almond skins (industrially obtained by removing bran from the nut) in SCI. NS and BS (30 mg/kg respectively) were administered per os, 1 h and 6 h, after SCI. RESULTS: SCI in mice resulted in severe injury characterized by edema, tissue damage, production of inflammatory mediators and apoptosis (measured by Bax, Bcl-2 and Tunel assay). NS treatment, 1 and 6 h after SCI, reduced all parameters of inflammation as neutrophil infiltration, NF-κB activation, PAR formation, iNOS expression and apoptosis. However, treatment with BS did not exert any protective effect. CONCLUSIONS: Our results suggest that NS treatment, reducing the development of inflammation and tissue injury, may be useful in the treatment of SCI. |
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Authors:
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G Mandalari; T Genovese; C Bisignano; E Mazzon; M S J Wickham; R Di Paola; G Bisignano; S Cuzzocrea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 30 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 221-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Pharmaco-Biological Department, University of Messina, Vill. SS: Annunziata 98168, Messina, Italy; Model Gut Platform, Institute of Food Research, Norwich Research Park, NR4 7UA, Norwich, UK. |
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