Document Detail

Neuroprotective effects of T-817MA against noise-induced hearing loss.
MedLine Citation:
PMID:  18343519     Owner:  NLM     Status:  MEDLINE    
Oxidative stress, including reactive oxygen species and other free radicals, is thought to play an important role in neuronal cell death, including noise-induced hearing loss. 1-{3-[2-(1-Benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate (T-817MA), a novel neurotrophic agent, protects against oxidative stress-induced neurotoxicity. This study examines the effects of T-817MA in noise-induced ototoxicity in the cochlea. Guinea pigs received treatment with T-817MA-enhanced water (0.2, 0.7 mg/ml) or untreated water (control) beginning 10 days prior to noise exposure and continuing through this study. All subjects were exposed to 4-kHz octave-band noise at 120-dB SPL for 5h. Auditory thresholds were assessed by sound-evoked auditory brainstem response at 4, 8, and 16kHz, prior to and 10 days following noise exposure. Hair cell damage was analyzed by quantitative histology. T-817MA significantly reduced threshold deficits and hair cell death. These results suggest T-817MA reduces noise-induced hearing loss and cochlear damage, suggesting functional and morphological protection.
Daisuke Yamashita; Akihiro Shiotani; Sho Kanzaki; Masaya Nakagawa; Kaoru Ogawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-29
Journal Detail:
Title:  Neuroscience research     Volume:  61     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Department of Otolaryngology, Keio University Hospital, 35 Shinanomachi, Shinjuku-Ku, Tokyo, Japan.
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MeSH Terms
Cochlea / pathology
Evoked Potentials, Auditory, Brain Stem / physiology
Guinea Pigs
Hair Cells, Auditory / pathology
Hearing Loss, Noise-Induced / prevention & control*
Maleates / pharmacology*
Neuroprotective Agents / pharmacology*
Noise / adverse effects
Oxidative Stress / physiology
Thiophenes / pharmacology*
Reg. No./Substance:
0/1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate; 0/Maleates; 0/Neuroprotective Agents; 0/Thiophenes

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