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Neuroprotective effects of 17β-estradiol associate with KATP in rat brain.
MedLine Citation:
PMID:  23032400     Owner:  NLM     Status:  In-Data-Review    
Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates KATP channel activity; the present study was designed to address the involvement of KATP channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, KATP mRNA and protein in the cortices of rats were compared among groups of ovariectomized rats (Ovx-1), Sham-operated rats (Sham-1), and ovariectomized rats administered 17β-estradiol (Estr-1). In experiment 2, neurobehavioral scores and infarct volume of rats were evaluated after middle cerebral artery occlusion in ovariectomized rats (Ovx-2), Sham-operated rats (Sham-2), ovariectomized female rats administered 17β-estradiol (Estr-2), and ovariectomized rats administered both 17β-estradiol and stereotactic injections of glibenclamide (Estr+G). Our results showed that the Kir6.2 and SUR1 mRNA and protein levels in the brain cortices of female ovariectomized rats were lower than those in Sham rats. However, the expression levels of Kir6.2 and SUR1 in brain cortices of ovariectomized rats recovered after supplementation with 17β-estradiol. The protective effects of 17β-estradiol were abolished by glibenclamide, a KATP channel blocker. This indicates that estradiol significantly upregulates the expression of KATP channel subunits and channel activity in the brain cortices of ovariectomized rats. This regulation is associated with the neuroprotective effects of estradiol.
Dengwen Zhang; Hui Xia; Lin Xu; Chuanhan Zhang; Wenlong Yao; Yu Wang; Jing Ren; Jinjing Wu; Yuke Tian; Wei Liu; Xueren Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  23     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  952-7     Citation Subset:  IM    
aDepartment of Anesthesiology, Tongji Hospital, Tognji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei bDepartment of Pharmacy, Hospital of PLA, Taian, Shandong, China.
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