| Neuroprotective effect of volatile anesthetic agents: molecular mechanisms. | |
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MedLine Citation:
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PMID: 19298752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Intra-operative cerebral ischemia can be catastrophic, and volatile anesthetic agents have been recognized for their potential neuroprotective properties since the 1960s. In this review, we examine the neuroprotective effects of five volatile anesthetic agents in current or recent clinical use: isoflurane, sevoflurane, desflurane, halothane and enflurane. METHODS: A review of publications in the National Library of Medicine and National Institutes of Health database from 1970 to 2007 was conducted. RESULTS: Volatile anesthetic agents have been shown to be neuroprotective in multiple animal works of ischemic brain injury. Short-term neuroprotection (<1 week post-ischemia) in experimental cerebral ischemia has been reported in multiple works, although long-term neuroprotection (> or = 1 week post-ischemia) remains controversial. Comparison works have not demonstrated superiority of one specific volatile agent over another in experimental models of brain injury. Relatively few human works have examined the protective effects of volatile anesthetic agents and conclusive evidence of a neuroprotective effect has yet to emerge from human works. CONCLUSION: Proposed mechanisms related to the neuroprotective effect of volatile anesthetic agents include activation of ATP-dependent potassium channels, up-regulation of nitric oxide synthase, reduction of excitotoxic stressors and cerebral metabolic rate, augmentation of peri-ischemic cerebral blood flow and up-regulation of antiapoptotic factors including MAP kinases. |
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Authors:
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Gerald A Matchett; Martin W Allard; Robert D Martin; John H Zhang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Neurological research Volume: 31 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 128-34 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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administration & dosage* Animals Brain Ischemia / metabolism, physiopathology, prevention & control* Databases, Factual / statistics & numerical data Disease Models, Animal Humans Ion Channels / drug effects Neuroprotective Agents / administration & dosage* Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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NS43338/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Ion Channels; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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