| Neuroprotective effect of graded postischemic reoxygenation in spinal cord ischemia in the rabbit. | |
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MedLine Citation:
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PMID: 9250619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early ischemia/reperfusion-induced changes of four phospholipid compounds bound to the inner cell membrane leaflet, i.e., phosphatidic acid, inositol phospholipids, serine phospholipids, and ethanolamine plasmalogens, were studied in a model of spinal cord ischemia in the rabbit during normoxic and graded postischemic reoxygenation. Light and electron microscopic analysis after normoxic reoxygenation disclosed neuronal membrane argyrophilia of the interneuronal pool located in lamina VII of L4-L6 segments. The number of small neurons (10-25 microm in diameter) affected by somatodendritic argyrophilia was greatly reduced, and concomitantly the ultrastructure of the endoplasmic reticulum, mitochondria, and Golgi complexes remained almost undamaged when graded postischemic reoxygenation had been applied. A statistically significant increase of phosphatidylserine and ethanolamine plasmalogen levels, and a decrease of phosphatidic acid, were detected after a short-lasting graded postischemic reoxygenation. The formation of thiobarbituric acid-reactive substances was significantly reduced during 60 min of graded postischemic reoxygenation and remained close to control or ischemic levels. The present data indicate that graded postischemic reoxygenation, which is considered to be neuroprotective, can prevent neuronal argyrophilia and the development of reperfusion-induced alterations of organelles. Moreover, reoxygenation can positively modify ischemia-induced changes of some membrane-bound phospholipids. |
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Authors:
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N Lukácová; M Marsala; G Halát; J Marsala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 43 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 457-65 Citation Subset: IM |
Affiliation:
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Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytoplasm / ultrastructure Ischemia / pathology* Ischemic Preconditioning* Lipid Peroxidation / drug effects Male Membrane Lipids / metabolism Microscopy, Electron Phospholipids / metabolism Rabbits Reperfusion Spinal Cord / blood supply*, pathology Thiobarbituric Acid Reactive Substances |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Phospholipids; 0/Thiobarbituric Acid Reactive Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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