| Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. | |
| | |
MedLine Citation:
|
PMID: 12798674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study is designed to investigate the effect of dietary flavanoid rutin, micronutrient selenium and garlic oil on ischaemia and reperfusion-induced cerebral injury. Global cerebral ischaemia was induced by occluding right and left common carotid arteries for 10min followed by reperfusion for 24h. Cerebral infarct size was estimated using triphenyltetrazolium chloride staining. Elevated plus maze was employed to estimate short-term memory. Degree of motor incoordination was evaluated using inclined beam-walking test and lateral push test. Mitochondrial thiobarbituric acid reactive substances (TBARS) assay was employed as an index of oxidative stress. Global cerebral ischaemia followed by reperfusion produced a significant impairment in short-term memory and motor coordination and produced a notable increase in mitochondrial TBARS. Administration of rutin and garlic oil before global cerebral ischaemia markedly reduced cerebral infarct size and attenuated impairment in short-term memory and motor coordination. Administration of sodium selenite either before or after global cerebral ischaemia markedly reduced cerebral infarct size and attenuated impairment in short-term memory and motor coordination. The protective effect of rutin, sodium selenite and garlic oil was accompanied by a marked decrease in mitochondrial TBARS. On the basis of these results, it may be suggested that rutin and garlic oil administrated before cerebral ischaemia may scavenge reactive oxygen species and consequently attenuate global cerebral ischaemia and reperfusion-induced cerebral injury. Sodium selenite administrated before and after cerebral ischaemia may be neuroprotective due to its antioxidant effect. |
| | |
Authors:
|
Ram Gupta; Manjeet Singh; Ajay Sharma |
Related Documents
:
|
8014664 - Cerebral infarction within six hours of onset: prediction of completed infarction with ... 7123594 - Pentobarbital protection from cerebral infarction without suppression of edema. 20975774 - Diagnostic and pathophysiological impact of myocardial mibg scintigraphy in parkinson's... 15258784 - Cerebral microembolism during transcatheter closure of patent foramen ovale. 8014664 - Cerebral infarction within six hours of onset: prediction of completed infarction with ... 22696494 - Left atrial volume and function in patients following st elevation myocardial infarctio... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 48 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-06-11 Completed Date: 2004-06-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
|
Languages: eng Pagination: 209-15 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 147002, Punjab, Patiala, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allyl Compounds
/
pharmacology,
therapeutic use* Animals Antioxidants / pharmacology, therapeutic use* Brain Ischemia / drug therapy* Cerebral Infarction / etiology, prevention & control* Data Interpretation, Statistical Disease Models, Animal Female Male Memory Disorders / etiology, prevention & control Memory, Short-Term / drug effects Mice Micronutrients / pharmacology, therapeutic use Mitochondria / metabolism Reactive Oxygen Species / metabolism Reperfusion Injury / complications, drug therapy* Rutin / pharmacology, therapeutic use* Sodium Selenite / pharmacology, therapeutic use* Sulfides / pharmacology, therapeutic use* Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Allyl Compounds; 0/Antioxidants; 0/Micronutrients; 0/Reactive Oxygen Species; 0/Sulfides; 0/Thiobarbituric Acid Reactive Substances; 10102-18-8/Sodium Selenite; 153-18-4/Rutin; 592-88-1/allyl sulfide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of Hypericum perforatum and paroxetine on rat performance in the elevated T-maze.
Next Document: Determination of paroxetine in geriatric depression by high-performance liquid chromatography.