| Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats. | |
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MedLine Citation:
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PMID: 19276616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post-ischemic treatment with KGK (10 - 300 mg/kg) and aspirin (5 mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area. |
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Authors:
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Fengling Pu; Kyoko Motohashi; Tomohiro Kaneko; Yurika Tanaka; Naomi Manome; Keiichi Irie; Jirou Takata; Nobuaki Egashira; Ryozo Oishi; Takuya Okamoto; Yasuo Sei; Takako Yokozawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara |
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Publication Detail:
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Type: Journal Article Date: 2009-03-11 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 109 ISSN: 1347-8613 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 424-30 Citation Subset: IM |
Affiliation:
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Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / pharmacology Brain Ischemia / drug therapy*, physiopathology Cell Death / drug effects Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Drugs, Chinese Herbal / administration & dosage, pharmacology* Hippocampus / blood supply, drug effects Laser-Doppler Flowmetry Male Maze Learning / drug effects Memory Disorders / drug therapy*, physiopathology Neurons / drug effects, metabolism Neuroprotective Agents / administration & dosage, pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Kangen-karyu; 0/Neuroprotective Agents; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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