| Neuroprotective Effect of Physical Exercise in a Mouse Model of Alzheimer's Disease Induced by β-Amyloid(1-40) Peptide. | |
| | |
MedLine Citation:
|
PMID: 23307759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
This study was designed to investigate the potential neuroprotective effect of exercise in a mouse model of Alzheimer's disease (AD) induced by intracerebroventricular (i.c.v.) injection of beta-amyloid(1-40) (Aβ(1-40)) peptide. For this aim, male Swiss Albino mice were submitted to swimming training (ST) with progressive increase in intensity and duration for 8 weeks before Aβ(1-40) administration (400 pmol/animal; 3 μl/site, i.c.v. route). The cognitive behavioral, oxidative stress, and neuroinflammatory markers in hippocampus and prefrontal cortex of mice were assessed 7 days after Aβ(1-40) administration. Our results demonstrated that ST was effective in preventing impairment in short- and long-term memories in the object recognition test. ST attenuated the increased levels of reactive species and decreased non-protein thiol levels in hippocampus and prefrontal cortex induced by Aβ(1-40). Also, Aβ(1-40) inhibited superoxide dismutase activity and increased glutathione peroxidase, glutathione reductase, and glutathione S-transferase activities in hippocampus and prefrontal cortex-alterations that were mitigated by ST. In addition, ST was effective against the increase of tumor necrosis factor-alpha and interleukin-1 beta levels and the decrease of interleukin-10 levels in hippocampus and prefrontal cortex. This study confirmed the hypothesis that exercise is able to protect against some mechanisms of Aβ(1-40)-induced neurotoxicity. In conclusion, we suggest that exercise can prevent the cognitive decline, oxidative stress, and neuroinflammation induced by Aβ(1-40) in mice supporting the hypothesis that exercise can be used as a non-pharmacological tool to reduce the symptoms of AD. |
| | |
Authors:
|
Leandro C Souza; Carlos B Filho; André T R Goes; Lucian Del Fabbro; Marcelo G de Gomes; Lucielli Savegnago; Mauro Schneider Oliveira; Cristiano R Jesse |
Related Documents
:
|
19169389 - Appropriateness of sling immobilization to prevent lead displacement after pacemaker/im... 23147689 - Beta blockers therapy is associated with improved left ventricular systolic function an... 22973219 - Beta- and gamma-range human lower limb corticomuscular coherence. 3383469 - Rate-responsive pacing with a pacemaker that detects respiratory rate (biorate): clinic... 2582729 - Cardiac repolarization properties during standardized exercise test as studied by qt, q... 2220619 - Circadian rhythmicity of rate-normalized qt interval in hypothyroidism and its signific... 17879879 - Fatigue responses in exercise under control of vo2. 19952839 - Water treadmill parameters needed to obtain land treadmill intensities in runners. 22129819 - The third heart sound after exercise in athletes: an exploratory study. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-11 |
Journal Detail:
|
Title: Neurotoxicity research Volume: - ISSN: 1476-3524 ISO Abbreviation: Neurotox Res Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100929017 Medline TA: Neurotox Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas - LaftamBio Pampa, Universidade Federal do Pampa, Itaqui, RS, CEP 97650-000, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B.
Next Document: Segmented Tetrasulfonated Copoly(Arylene Ether Sulfone)s: Improving Proton Transport Properties by E...