| Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. | |
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MedLine Citation:
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PMID: 21056650 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGICAL RELEVANCE: Momordica charantia L. (Cucurbitaceae) fruits have been used traditionally for centuries, especially for treating diabetes and associated complications. AIM OF THE STUDY: The present study was performed to evaluate neuroprotective effect of lyophilized M. charantia fruit juice against global cerebral ischemia and reperfusion induced neuronal injury in diabetic mice. MATERIALS AND METHODS: Global cerebral ischemia induced by occluding both common carotid arteries for 10min followed by 24h reperfusion was used to induce neuronal injury. Ischemia-reperfusion induced neuronal injury was evaluated in terms of cerebral infarct size, generation of free radicals measured as thiobarbaturic acid reactive substances (TBARS), and neurological functions measured as short term memory and motor activity. RESULTS: The cerebral oxidative stress and damage, and neurological deficits were dose dependently attenuated by pre-treatment with the lyophilized M. charantia juice (200-800mg/kg, p.o., o.d.). Moreover, M. charantia also exhibited dose dependent antihyperglycemic activity in diabetic mice. CONCLUSIONS: These results suggest that M. charantia has potent neuroprotective activity against global cerebral ischemia-reperfusion induced neuronal injury and consequent neurological deficits in diabetic mice. |
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Authors:
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Zafar Ahmad Malik; Manjeet Singh; P L Sharma |
Publication Detail:
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Type: Journal Article Date: 2010-11-05 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 133 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 729-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology, ISF College of Pharmacy, Gal Kalan, Ferozpur Road, Moga, Punjab 142001, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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