| Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. | |
| | |
MedLine Citation:
|
PMID: 20333481 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Ketogenic diet (KD) is a high-fat, low-protein and low-carbohydrate diet. It is reported that KD can provide the neuroprotection for the neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD) and amyotrophic lateral sclerosis. The main clinical symptom of PD is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (SN) and dopamine content in the striatum subsequently. It is well known that treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice produce motor dysfunction, biochemical, and neurochemical changes remarkably similar to idiopathic PD patients. In this study, we investigated the neuroprotective and anti-inflammatory effects of KD in MPTP-treated mice. The data showed that pretreatment with KD alleviated the motor dysfunction induced by MPTP. The decrease of Nissl-staining and tyrosine hydroxylase (TH)-positive neurons induced by MPTP was inhibited in the SN. The change of dopamine was very similar to dopaminergic neurons in the SN. KD inhibited the activation of microglia induced by MPTP in the SN. The levels of proinflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha) in the SN were also decreased and induced by MPTP. So, we concluded that KD was neuroprotective and anti-inflammatory against MPTP-neurotoxicity. |
| | |
Authors:
|
Xinxin Yang; Baohua Cheng |
Publication Detail:
|
Type: Journal Article Date: 2010-03-24 |
Journal Detail:
|
Title: Journal of molecular neuroscience : MN Volume: 42 ISSN: 1559-1166 ISO Abbreviation: J. Mol. Neurosci. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002991 Medline TA: J Mol Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 145-53 Citation Subset: IM |
Affiliation:
|
Department of Human Anatomy, Jining Medical College, 45 Jianshe Nanlu, Jining City, Shandong Province, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hybrid repair of a symptomatic thoracic intra-mural haematoma.
Next Document: ABC transporters as molecular effectors of pancreatic oncogenic pathways: the Hedgehog-GLI model.